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Malignant Peritoneal Mesothelioma Complicating FamilialMediterranean Fever on 18F-FDG PET/CT

Antoine Fayand, MD,* Khaldoun Kerrou, MD,† Dominique Wendum, MD, PhD,‡

Gilles Grateau, MD, PhD,* and Sophie Georgin-Lavialle, MD, PhD*

Mésothéliome péritonéal malin compliquant une Fièvre Méditerranéenne Familiale sur la TEP/CT au 18F-FDG


A 77-year-old man with a personal history of familial Mediterranean fever presented with a slowly enlarging tumefaction of the left abdominal wall and persistent inflammatory syndrome despite good adherence to colchicine. 18F-FDG PET/CT showed a hypermetabolic muscular mass of the abdominal wall along with other hypermetabolic lesions including a peritoneal mass and several subcutaneous soft tissue nodules.

CT-guided needle biopsy led to the diagnosis of a muscular localization of a malignant peritoneal mesothelioma, which is an extremely rare complication of familial Mediterranean fever. Six courses of chemotherapy with carboplatin and pemetrexed allowed an almost complete response.

Key Words: malignant peritoneal mesothelioma, familial Mediterranean fever, autoinflammatory disorders, 18F-FDG PET/CT.

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